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Smiles: CCN1C(=O)C(=CC2=CN=C(NC3=CC(F)=C(C=C3)N3CCNCC3)N=C12)C1=CC=C(Cl)C=C1Cl
leaving normal cells almost unaffected
with antiallergic effects related to histamine antagonism
Kobe2602 may serve as a scaffold for the development of Ras inhibitors with higher potency and specificity
It showed a broad anti-inflammatory profile in a LPS-challenged Balb/C mouse model
CNX-1351 - CAS# 1276105-89-5 Catalog No.:M9803-10 Smiles: CCN1C(=O)C(=CC2=CN=C(NC3=CC(F)=C(C=C3)N3CCNCC3)N=C12)C1=CC=C(Cl)C=C1ClCNX 1351 is a selective covalent Inhibitor of PI3K. In an end point assay, CNX 1351 potently inhibited PI3K and was 20400 times less potent against , , and . CNX 1351 inhibit PI3K signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX 1351 inhibits growth of cells dependent on PI3K. CNX 1351 also inhibits PI3K signaling in vivo and bonds to p110. Product information CAS Number: 1276105 89 5 Molecular
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